Hongyu Qiu, M.D., Ph.D., is a professor in the Center for Molecular & Translational Medicine and the Institute of Biomedical Sciences (IBMS).
Dr. Qiu has a broad background in clinical medicine and basic science with specific training and expertise in physiology and molecular biology of cardiovascular diseases. Her work has contributed to the advancement of the field by characterizing the molecular mechanisms and physiological functions of novel genes in protecting against cardiovascular diseases and aging deterioration.
One portion of her research focuses on the discovery and characterization of novel genes involved in the cardiac protection against myocardial ischemia and pressure-overload induced heart failure. By using the different genetically-modified mouse models (TG and KO mice), her lab has established a serial of the genomic and physiological studies both in vitro and in vivo, and has developed the line of the research on the exploration of novel signaling pathways regulating the cardiomyocyte survival and growth under the cardiac stress. The goal of her research is to better understand the mechanisms and physiological relevance of the protective effects of the novel genes against myocardial damage and explore the therapeutic potential.
Dr. Qiu also studies the cellular and molecular mechanism of aortic stiffness during the development of hypertension and aging. Her group particular interests in elucidating the role of intrinsic elasticity and extrinsic regulation of aortic vascular smooth muscle cell (VSMC) in the development of aortic stiffness and their relationship with the regulation of blood pressure. By combining novel bio-engineering techniques, including atomic force microscopy and reconstituted tissue model, with molecular medicine, her lab is chasing the contribution of VSMC stiffness to the development of aortic stiffness at tissue and single cell level, and the underlying molecular mechanisms. This project represents a novel research direction and may open new avenues for hypertension therapy at the level of VSMC, particularly in elder.
Dr. Qiu’ s research has been supported by grants from American Heart Association, National Institute of Health and several other foundations.