Our Work

The research agenda for the Center for Molecular and Translational Medicine at Georgia State University include:

  • Coronary heart diseases and stroke;
  • Obesity and diabetes;
  • Atherosclerosis and vulnerable plaques
  • Aortic aneurysm / dissections;
  • High blood pressure disorders;
  • Septic shock;
  • Aging;
  • Vascular biology of tumors; and
  • Impacts of smoking (nicotine, i.e., electronic cigarette) on human health and diseases.

List of the center members’ publications and presentations since 2010:

  1. Shirwany NA, Zou MH. AMPK in cardiovascular health and disease. Acta Pharmacol Sin. 31(9):1075-84, 2010 PMCID: PMC3078651
  2. Shirwany NA, Zou MH. Arterial Stiffness: A Brief Review. Acta Pharmacol Sin. 31(10):1267-76, 2010 PMCID: PMC3078647
  3. Wang, S., Dale, G., Song, P., Viollet, B., Zou, M.H. AMPK alpha 1 deletion shortens erythrocyte lifespan in mice, role of oxidative stress. Biol. Chem. 285(26):19976-85, 2010 PMCID 2888409
  4. Li YJ, Wang PH, Chen C, Zou MH, Wang DW. Improvement of mechanical heart functions by trimetazidine in db/db mice. Acta Pharmacol. Sin. 31(5):560-9, 2010 PMCID: PMC2953963
  5. Liu, C., Liang, B., Wu, J., Zou, M.H., Activation of the AMP-activated protein kinase alpha 1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins BCL-2 and survivin. Biol. Chem., 285:15346–15355, 2010. PMCID: PMC2865290
  6. Dong, Y., Zhang, M., Wang, S., Liang, B., Zhao, Z., Liu, C., Wu, M., Choi, H., Lyons, T., Zou, M.H., Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes 59(6):1386-96, 2010 PMCID: PMC2874699
  7. Wang, S., Zhang, M., Xie, Z., Viollet, B., Zou, M.H. AMPK alpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo role of 26S proteasomes. Res. 106:1117-28, 2010. PMCID: PMC2888409
  8. Dong, Y., Zhang, M., Liang, B., Xie, Z., Choi, H., Zou, M.H., Reduction of AMP-activated protein kinase alpha 2 increased endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 121(6):792-803, 2010. PMCID: PMC2825900
  9. Zou, MH. Is NAD(P)H Oxidase a Missing Link for Air Pollution-Enhanced Obesity? Thromb. Vasc. Biol. 30(12):2323-2324, 2010 PMCID: PMC3075439
  10. Zhang, M., Xu, J., Song, P., Zou, M.H. Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Thromb. Vasc. Biol. 31(1):125-32, 2011. PMCID: PMC3005129
  11. Han, Y., Wang, Q., Zhu, Y., Zou, M.H., Redox regulation of AMP-activated protein kinase. PLoS ONE. 5;5(11):e15420, 2010. PMCID: PMC2974634
  12. Wang, Q., Shirwany, N., Xu, J., Liang B., Zou, M.H. 2-deoxyglucose-induced autophagy inhibits endothelial cell apoptosis. PLoS One. 6(2):e17234, 2011. PMCID: PMC3046135
  13. Wang, S., Viollet, B., Zou, M.H. activated Protein Kinase Alpha 2 Accentuates Agonist-Induced Vascular Smooth Muscle Contraction and High Blood Pressure in Mice. Hypertension 57:1010-1017, 2011. PMCID: PMC3089757
  14. Xu, M., Song, P., Shirwany, N., Xing, Viollet, B., J., Wang, X., Zhu, Y., Zou, M.H. Impaired Expression of Uncoupling Protein 2 (UCP-2) Causes Defective Post-ischemic Angiogenesis in Mice Deficient of AMP-activated Protein Kinase α2 Subunits. Thromb. Vasc. Biol. 31:1757-1765, 2011. PMCID: PMC3158995
  15. Xie Z, Lau K, Eby B,  Lozano P, He C, Pennington B, Dong Y,  Rathi S, Tian R, Kem D,  Zou MH. Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice. Diabetes. 60(6):1770-8, 2011. PMCID: PMC3114402
  16. Xie Z, He C, Zou M.H. AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy. Autophagy. 7(10):1254-5, 2011. PMCID: PMC3210311
  17. Zhu Z, Fu C, Li X, Song Y, Li C, Zou, M.H, Guan Y, Zhu Y. Prostaglandin E2 Promotes Endothelial Differentiation from Bone Marrow-Derived Cells through AMPK Activation. PLoS One 6(8):e23554, 2011. PMCID: PMC3158081
  18. Wang, Q., Liang, B., Zhang, M., Viollet, B., Zhu, Y., Zou, M.H. Berberine Attenuates Oxidative Stress and Atherosclerosis in Mice in vivo: Roles of the AMP-activated Protein Kinase. PloS One 6(9):e25436, 2011. PMCID: PMC3181327
  19. Shirwany, N. and Zou, M.H. Vascular inflammation as a missing link for enhanced cardiovascular diseases in diabetes. Frontier in Bioscience (Landmark Edition, Invited Review). 17:1140-64, 2012.
  20. Zou, M.H, Li, H., He, C., Lyons, T., Xie, Z. Tyrosine Nitration of Prostacyclin Synthase Is Associated with Enhanced Retinal Cell Apoptosis in Diabetes. J. Path. 179:2835–2844, 2011. PMCID: PMC3260825
  21. Song, P., Wang, S., He, C., Wang, S., Liang, B., Zhang, W., Zou, M.H. AMPKα2 Deletion Exacerbates Neointimal Formation by Upregulating Skp2 in Vascular Smooth Muscle Cells in vivo. Res. 109(11):1230-9, 2011. PMCID: PMC3235405
  22. Wu, Y., Dong, Y., Song, P., Zou, M-H. Activation of the AMP-activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells. PloS One 7(2):e31056, 2012. PMCID: PMC3281919
  23. Xu, J., Wang, S., Zhang, M., Wang, Q., Asfa, S., Zou, M.H. Tyrosine nitration of PA700 links proteasome activation to endothelial dysfunction in mouse models with cardiovascular risk factors. PloS One 7(1):e29649, 2012. PMCID: PMC3260160
  24. Wang, S., Zhang C., Liang, B., Zhang, M., Lee, J., Zhu, H., Viollet, B., Xia, L., Zhang Y., and Zou, M.H. Activation of AMP-activated Protein Kinase alpha2 by Nicotine Instigates the Formation of the Abdominal Aortic Aneurysms in Mice in vivo. Nature Medicine 18(6):902-10, 2012 (Accompanied with editorial commentary). PMCID: PMC3559018
  25. Wang, S., Song, P., Zou, M.H. AMP-activated Protein Kinase, Stress Responses, and Cardiovascular Diseases. Clinical Science 122, 555–573, 2012. PMCID: PMC3367961
  26. Wang, S., Song, P., Zou, M.H. Inhibition of AMPKα1 by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts: role of p53 and SIRT1. Biol. Chem. 287(11):8001-12, 2012. PMCID: PMC3318690
  27. Song, P. and Zou, M.H. (Invited Review) Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radical Biol. Med. 52(9):1607-19, 2012. PMCID: PMC3341493
  28. Wu, Y., Wang, S., Xu, J., Song, P., Viollet, B., and Zou, M.H. Activation of the AMP-activated Protein Kinase by Eicosapentaenoic Acid (EPA, 20:5 n-3) Improves Endothelial Function in vivo. Plos One. 7(4):e35508, 2012. PMCID: PMC3330125
  29. Xu, J., Wang, S., Viollet, B., and Zou, M.H, Regulation of proteasome by AMPK: The role of O-GlcNAc transferase (OGT). Plos One. 7(5):e36717, 2012. PMCID: PMC3345026
  30. Liu, C., Wu, J. L., and Zou, M.H. Activation of AMP-activated protein kinase alleviates high glucose-induced dysfunction of brain endothelial cell tight junction dynamics. Free Radical Biol. & Med. 14;53(6):1213-1221, 2012 PMCID: PMC3437014
  31. Zhao, Y., Zhu, H., Zou, M.H. Non-Covalent Interaction between Polyubiquitin and GTP Cyclohydrolase 1 Dictates Its Degradation. PLoS One. 7(9):e43306, 2012. PMCID: PMC3440371
  32. Yang, S, Chen, C, Wang, H, Rao, X, Wang, F, Duan, Q, Chen, F, Long, G, Gong, W, Zou, M. H., Wang, DW. Protective effects of acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling. PLoS One. 7(11):e50376, 2012. PMCID: PMC3511550
  33. Yao, L., Heuser-Baker, J., Herlea-Pana, O., Iida, R., Wang, Q., Zou, M. H. Barlic-Dicen, J. Bone Marrow Endothelial Progenitors Augment Atherosclerotic Plaque Regression in a Mouse Model of Plasma Lipid Lowering. Stem Cells. 30(12):2720-31, 2012. PMCID: PMC3508339
  34. He, C., Zhu, H., Li, H, Zou, M. H. (Corresponding authors) and Xie, Z. Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes. Diabetes. 62(4):1270-81, 2013. PMCID: PMC3609561
  35. Xing, J., Wang, Q., Coughlan, K., Viollet, B., Moriasi, CM., and Zou, M.H. Inhibition of AMP-Activated Protein Kinase Accentuates Lipopolysaccharide-Induced Lung Endothelial Barrier Dysfunction and Lung Injury in Vivo. J. Pathol. 182(3):1021-30, 2013. PMCID: PMC3589075
  36. Liang, B, Wang, S., Wang, Q., Zhang, W., Viollet, B., Zhu, Y., Zou, M.H. Aberrant Endoplasmic Reticulum Stress in Vascular Smooth Muscle Increases Vascular Contractility and Blood Pressure in Mice Deficient of AMP-activated Protein Kinase alpha 2 in vivo. ATVB. 33(3):595-604, 2013. PMCID: PMC Journal – In Process
  37. Zhang, W., Wang, Q., Song, P., Zou, M.H. Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation. 62(7):2347-58, 2013. PMCID: PMC Journal – In Process
  38. Zou, M.H. and Xie, Z. Regulation of interplay between autophagy and apoptosis in the diabetic heart: New role of AMPK. Autophagy. 9(4):624-5, 2013. PMCID: PMC Journal – In Process
  39. He, J., Zhou, Y., Xing, X., Wang, Q., Zhu, H., Zhu, Y, Zou, M.H. Liver kinase B1 is required for thromboxane receptor-dependent NF-κB activation and inflammatory responses. Thromb. Vasc. Biol. 33(6):1297-305, 2013. PMCID: PMC Journal – In Process
  40. Zhu H, Moriasi CM, Zhang M, Zhao Y, Zou MH. Phosphorylation of Serine 399 in LKB1 Short Form by Protein Kinase Cζ is required for its Nucleocytoplasmic Transport and Consequent AMPK Activation. Biol. Chem. 288(23):16495-505, 2013. PMCID: PMC Journal – In Process
  41. Song, Y., Li, X., Wang, D., Fu, C., Zhu, Z., Zou, M.H. (co-corresponding author), Zhu, Y. Transcription factor Krüppel-like factor 2 plays a vital role in endothelial colony forming cells differentiation. Cardiovascular Research 99(3):514-24, 2013. PMCID: PMC Journal – In Process
  42. Zhao, Y., Wu, J., Zhu, H., Song, P., Zou, M.H. Peroxynitrite-dependent Zinc Release and Inactivation of Guanosine 5′-triphosphate Cyclohydrolase 1 instigates its Ubiquitination in Diabetes. Diabetes 62(12):4247-56, 2013.
  43. Song, P., Zhou, Y., Coughlan, K.C., Dai, X., Xu, H., Viollet, B., Zou, M.H. Adenosine Monophosphate-activated Protein Kinase-α2 Deficiency Promotes Vascular Smooth Muscle Cell Migration via Skp2 Upregulation and E-cadherin Downregulation. Thromb. Vasc. Biol. 33(12):2800-9, 2013
  44. Wang, Q., Zhang, M., Ding, Y., Wang, Q., Zhang, W., Song, P., Zou, M.H. Activation of NAD(P)H Oxidase by tryptophan-derived 3-hydroxykynurenine Accelerates Endothelial Apoptosis and Dysfunction In Vivo. Circulation Research 114:480-492, 2014 (Accompanied with editorial commentary)
  45. Okon, I., Coughlan, A. K., Zou, M.H. Liver Kinase B1 Expression Promotes Phosphatase Activity and Abrogation of Receptor Tyrosine Kinase Phosphorylation in Human Cancer Cell Lines. Biol. Chem. 289(3):1639-48, 2014
  46. Li, H., Lee, J., He, C., Zou, M.H., and Xie, Z. Suppression of mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids. AJP-Endocrinology and Metabolism. 306(2):E197-209, 2014 PMCID3920006
  47. Shirwany, N. A., Zou, M. H. AMPK: A cellular metabolic and redox sensor. A minireview. Front Biosci (Landmark Ed). 19:447-74, 2014.
  48. Zhang, W., Wang, Q., Wu, Y., Moriasi, C., Liu, Z., Dai, X., Wang, Q., Liu, W., Yuan, Z.Y. Zou, M.H. Endothelial cell-specific LKB1 deletion causes endothelial dysfunction and hypertension in mice in vivo. Circulation. 129:1428-39, 2014 PMCID PMC3972325
  49. Zhu, H., Foretz, M., Xie, Z., Zhang, M., Xing, J., Leclerc, J., Gaudry, M., Viollet, B., Zou, M.H. AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation. 10:1522-34, 2014.
  50. Song, P. and Zou, M. H. Redox regulation of endothelial cell fate. Cell Mol Life Sci. 71(17):3219-39, 2014
  51. Li, H., Min, Q., Ouyang, C., Lee, Y., He, C., Zou, M.H., Xie, Z. AMPK Activation Prevents Excess Nutrient-induced Hepatic Lipid Accumulation by Inhibiting mTORC1 Signaling and Endoplasmic Reticulum Stress Response. BBA – Molecular Basis of Disease 1842(9):1844-54, 2014
  52. Okon, I.S., Coughlan,K.A., Zhang,C., Moriasi,C., Ding,Ye., Song,P., Zhang,W., Li,G., and Zou, M.H. Promotion of Rab7-mediated lysosome-dependent neuropilin-1 degradation by LKB1 inhibits angiogenesis in vivo. Journal of Clinical Investigation. 124(10):4590–4602, 2014
  53. Wang, Q., Xie, Z., Zhang, W., Zhou, J., Wu, Y., Zhang, M., Zhu, H., Zou, M.H. Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes, 63(12):4172-85, 2014 (Accompanied with editorial commentary)
  54. Xu, H., Zhou, Y., Coughlan, K.A., Ding, Y., Wang, S., Wu, Y., Song, P., Zou, M.H. AMPK<alpha>1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. BBA – Molecular Cell Research, 1853(1):65-73, 2015
  55. Zhou, Y., Wang, Q., Ding, Y., Zou, M.H., Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes. Journal of Molecular Endocrinology 54(1):25-37, 2015
  56. Liu, Z., Zhang, W., Zhang, M., Zhu, H., Moriasi, C., Zou, M. H. Liver kinase B1 suppresses lipopolysaccharides-induced NF-κB activation in macrophages. J. Biol. Chem. 290(4):2312-20, 2015
  57. Wu, Y., Song, P., Zhang, W., Liu, J., Dai, X., Liu, Z., Lu, Q., Ouyang, C., Xie, Z., Zhao, Z., Zhuo, X., Viollet, V., Foretz, M., Wu, J., Yuan, Z.Y., Zou, M.H. Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nature Medicine, 21(4):373-82, 2015.
  58. Wang, Z., Yu, D., Wang, M., Wang, Q., Kouznetsova, J., Yang, R., Qian, K., Wu, W., Shuldiner, A.R., Sztalryd, C., Zou, M.H., Zheng, W., and Gong, D. Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian System. Scientific Reports. 5:8170, 2015.
  59. Duan, Q., Yang, L., Gong, W., Chaugai, S., Wang, F., Chen, C., Wang, P., Zou, M.H., Wang, D.W. MicroRNA-214 is Up-Regulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis. Cell. Physiol. 230(8):1964-73, 2015.
  60. Okon, I.S., Coughlan, K.A., Zhang, M., Wang, Q., Zou, M.H. Gefitinib-mediated ROS instigates mitochondrial dysfunction and drug resistance in lung cancer cells. Biol. Chem. 3;290(14):9101-10, 2015
  61. Herlea-Pana, O., Yao, L., Heuser-Baker, J., Wang, Q., Wang, Q., Georgescu, C., Zou, M. H., Barlic-Dicen, J. Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone marrow endothelial progenitors during atherosclerotic plaque regression. Cardiovasc Res. 106(2):324-37, 2015.
  62. He, C., Li, H., Viollet, B., Zou, M.H., (corresponding author) and Xie, Z. AMP-activated Protein Kinase Suppresses Vascular Inflammation in vivo by Inhibiting Signal Transducer and Activator of Transcription-1. Diabetes, In press
  63. Wu, W., Zhang, W., Duggan, E.S., Booth, J.L., Zou, M.H., Metcalf, J.P. RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells. Virology. 10;482:181-188, 2015
  64. Wang, Q., Liu, D., Song, P., Zou, M.H. Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation. Front Biosci (Landmark Ed). 20:1116-43, 2015.
  65. Liu, Z., Dai, X., Zhu, H., Zhang, M., Zou, M.H. Lipopolysaccharides promoted S-nitrosylation and proteasomal degradation of liver kinase B1 in macrophage in vivo. Biol. Chem. 290(31):19011-7, 2015
  66. Okon, I.S., Zou, M. H. LKB1 in transmembrane receptor signaling. 6(19):16804-5, 2015.
  67. Okon, I.S., Zou, M. H. Mitochondrial ROS and cancer drug resistance: Implications for therapy. Pharmacol Res. 100:170-174, 2015
  68. Cai, Z., Lu, Q., Ding, Y., Wang, Q., Xiao, L., Song, P., Zou, M. H. Endothelial nitric oxide synthase-derived nitric oxide prevents dihydrofolate reductase degradation via promoting S-Nitrosylation. Arterioscler. Thromb. Vasc. Biol. 35(11):2366-73. (Accompanied with editorial commentary) 2015.  PMID:  26381869  PMCID:  PMC4758687
  69. Okon, I.S., Ding, Y., Coughlan, K.A., Wang, Q., Song, P., Benbrook, D.M., Zou, M. H. Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers. Oncotarget. 7(7):7970-8.  2016.  PMID:  26701889 NIHMSID790390
  70. Ding. Y., Chen, J., Okon, I.S., Zou, M.H., Song, P. Absence of AMPKα2 Accelerates Cellular Senescence via P16 Induction in Mouse Embryonic Fibroblasts. Int. J. Biochem. Cell. Biol. 71:72-80 2016.  PMID:  26718972  PMCID:  PMC4720555.
  71. Duan, Q., Ni, L., Wang, P., Chen, C., Yang, L., Ma, B., Gong, W., Cai, Z., Zou, M.H., Wang, D.W. eregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in vivo. Aging Cell 15(4):625-33, 2016
  72. Cai, Z., Ding, Y., Zhang, M., Lu, Q., Wu, S., Zhu, H., Song, P., Zou, M.H. Ablation of Adenosine Monophosphate-activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification in vivo. Circ. Res. 22;119(3):422-33, 2016 (accompanying commentary: :
  73. Ding, Y., Zhang, M., Zhang, W., Lu, Q., Cai, Z., Song, P., Okon, I.S., Xiao, L., and Zou, M.H. AMP-activated protein kinase alpha 2 deletion induces VSMC phenotypic switching and promotes atherosclerotic plaque instability. Circ. Res. ;119:718-730, 2016
  74. Wang, Q., Wu, S., Zhu, H., Ding, Y., Dai, X., Ouyang, C., Han, Y. M., Xie, Z., and Zou, M.H. Deletion of AMP-activated protein kinase-alpha triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of dynamin-related protein 1. Autophagy In press
  75. Zhu, H., Zhang, M., Liu, Z., Xing, J., Moriasi, C., Dai, X., and Zou, M.H. AMP-activated protein kinase (AMPK) α1 in macrophages promotes collateral remodeling and arteriogenesis in mice in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology 36(9):1868-78, 2016
  76. Zhou, Y., Xu, H., Ding, Y., Lu, Q., Zou M. H., Song, P. AMPKα1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. Oncotarget. 2016
  77. Wu, W., Zhang, W., Booth, J.L., Hutchings, D.C., Wang, X., White, V.L., Youness, H, Cross, C.D., Zou, M.H., Burian, D., Metcalf, J.P. Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses. Respir. Res. 17(1):111, 2016
  78. Chen, H.Z., Wang, F., Gao, P., Pei, J.F., Liu, Y., Xu, T.T., Tang, X., Fu, W.Y., Lu, J., Yan, Y.F., Wang, X.M., Han, L., Zhang, Z.Q., Zhang, R., Zou, M.H. (corresponding author), Liu, D.P. Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. Circ. Res. In press.
  79. Dai, X., Ding, Y., Liu, Z., Zhang, W., Zou, M. H. Phosphorylation of C/EBP Homologous Protein (CHOP) by the AMP-Activated Protein Kinase Alpha 1 in Macrophages Promotes CHOP Degradation and Reduces Injury-Induced Neointimal Disruption In Vivo. Circ. Res. In press
  80. Wang, Q., Zhang, M., Torres, G., Wu, S., Xie, Z., Zou, M. Metformin suppresses diabetes-accelerated atherosclerosis via the inhibition of Drp1-mediated mitochondrial fission. Diabetes. In press