The Center for Molecular and Translational Medicine at Georgia State University meets healthcare needs by converting significant research findings into diagnostic tools and medicines to improve the health of individuals. The center is designed to help millions of people suffering from heart disease, diabetes and other illnesses. The current research focus of the center is to dissect molecular insights of cardiovascular remodeling in obesity and obesity related diseases, including diabetes, hypertension, heart diseases, and stroke, with special emphasis on the regulation of these processes.
Utilizing a multidisciplinary approach encompassing all aspects of modern biology, including structural biology, cell biology, protein chemistry, structure-function analysis of enzymes and receptors, regulation of the relevant genes, and in vivo studies using transgenic and gene deletion approaches, scientists in the section of Molecular Medicine employ physical, chemical, biological and medical techniques to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them.
The center’s multidisciplinary approach allows identification of new factors and the mechanisms that regulate over nutrition, obesity and inflammation and enables translation of these findings into an appreciation of their physiological role and clinical relevance. In addition to contributing to a fundamental understanding of these systems, the studies have clinical relevance to obesity and obesity-related cardiovascular diseases.
The center is poised to continue its research activity in the coming years with increasing urgency and determination with the recognition that the human diseases that have been the section’s research focus like diabetes, heart disease and obesity, have reached epidemic proportions in our communities. These disorders burden the economy of our nation and state with multibillion dollar expenditures and tremendous human cost. The center’s scientists are dedicated to the task of unraveling the mechanisms of these human health specters with the aim to invent new and more effective strategies to combat these diseases and ultimately to defeat them altogether.